USP13

Across TCGA cell cohorts, USP13 mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP13-associated genes across cancer lineages are RNASE8, MYH6, and PRAMEF14. Each is linked with USP13 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP13-to-partner and partner-to-USP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by USP13-low versus USP13-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP13→partner) and Y-score (partner→USP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNASE8 →	+0.078	+5.000	<.001	.006	3	1
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	PRAMEF14 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	SCYGR2 →	+0.133	+5.614	<.001	.002	3	1
OVARY	MAGEB4 →	+0.006	+4.700	<.001	.002	3	1
OVARY	MLN →	+0.667	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

RNASE8 by USP13 expression — PANCREAS

Explore this box plot interactively →