USP11

Across TCGA pan-cancer cohorts, USP11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP11 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher USP11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP11 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and CCRCC are the cancer types where USP11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.546	0.152	.001	19	view →
LSCC	DFS	Quartile	All	0.951	0.630	.005	18	view →
CCRCC	DFS	Median	All	0.845	0.646	.016	6	view →
PDAC	DFS	Median	III,IV	0.223	0.486	.023	5	view →
LUAD	DFS	Median	III,IV	0.542	0.938	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP11–GBM (DFS)

Open the GBM breakdown →