USP11

Across TCGA patient cohorts, USP11 protein abundance is significantly associated with the RNA expression of many other genes, with 11,630 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible USP11-associated genes across cancer lineages are SCML2, FANCB, and KRBOX4. Each is linked with USP11 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP11-to-partner and partner-to-USP11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP11 versus SCML2 in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP11→partner) and Y-score (partner→USP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SCML2 →	+0.910	+0.404	<.001	<.001	3	6
HNSC	FANCB →	+0.862	+0.355	<.001	<.001	3	6
HNSC	KRBOX4 →	+0.474	+0.317	<.001	<.001	3	5
UCEC	RAB39B →	+0.618	+0.421	<.001	<.001	3	5
HNSC	PM20D2 →	+1.131	+0.342	<.001	<.001	3	5
UCEC	DDIAS →	+0.845	+0.472	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,630 associations by consensus.

USP11 vs SCML2 — HNSC

Explore this scatter interactively →