USP11

Across TCGA patient cohorts, USP11 mutation is significantly associated with the RNA expression of many other genes, with 3,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP11-associated genes across cancer lineages are PI4K2A, ME2, and GZMB. Each is linked with USP11 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP11-to-partner and partner-to-USP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI4K2A grouped by USP11-low versus USP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP11→partner) and Y-score (partner→USP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI4K2A →	+0.226	+1.625	.005	.001	3	3
UCEC	ME2 →	+0.378	+1.680	.001	<.001	3	3
UCEC	GZMB →	+1.074	+2.643	<.001	<.001	3	3
UCEC	GABRE →	-0.449	-2.107	.009	<.001	3	3
UCEC	IFNG →	+0.729	+1.890	<.001	<.001	3	3
UCEC	SELENOS →	+0.301	+1.539	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

PI4K2A by USP11 expression — UCEC

Explore this box plot interactively →