USP11

Across TCGA patient cohorts, USP11 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP11-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and NDRG1_pT346. Each is linked with USP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP11-to-partner and partner-to-USP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by USP11-low versus USP11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP11→partner) and Y-score (partner→USP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1068 →	-0.196	-2.567	.008	.011	3	2
SKCM	mTOR_pS2448 →	-0.205	-2.584	.014	.011	3	2
SKCM	NDRG1_pT346 →	-0.764	-3.000	.012	.034	3	2
COAD	MSH2 →	-0.252	-2.991	.030	.036	3	2
COAD	C-Raf →	+0.175	+3.008	.021	.019	3	2
UCEC	ERK2 →	+0.190	+1.485	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by USP11 expression — SKCM

Explore this box plot interactively →