USP11

Across TCGA cell cohorts, USP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,389 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP11-associated GO terms across cancer lineages are Protein-DNA complex assembly, Regulation of transcription initiation by RNA polymerase II, and U2-type prespliceosome assembly. Each is linked with USP11 in more than 18 cancer types. Because this analysis shows association rather than direction, both USP11-to-partner and partner-to-USP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex assembly grouped by USP11-low versus USP11-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP11→partner) and Y-score (partner→USP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-DNA complex assembly →	+0.084	+1.072	<.001	<.001	3	19
BREAST	Regulation of transcription initiation by RNA polymerase II →	+0.074	+1.543	<.001	<.001	3	18
OESOPHAGUS	U2-type prespliceosome assembly →	+0.118	+1.268	.008	.003	2	18
BONE	Protein-DNA complex organization →	+0.085	+0.941	.001	.001	2	18
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.070	+1.254	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.082	+1.134	.002	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,389 associations by consensus.

Protein-DNA complex assembly by USP11 expression — LUNG_SCLC

Explore this box plot interactively →