USP10

Across TCGA patient cohorts, USP10 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP10-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ACC1. Each is linked with USP10 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP10-to-partner and partner-to-USP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP10-low versus USP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP10→partner) and Y-score (partner→USP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.712	+2.459	<.001	<.001	3	3
COAD	eIF4E →	+0.195	+2.820	.026	.035	3	2
UCEC	ACC1 →	+0.250	+1.598	.016	.019	3	2
UCEC	MEK1 →	+0.410	+2.000	<.001	<.001	3	2
UCEC	PDK1_pS241 →	+0.105	+1.392	.032	.017	3	2
UCEC	ATM →	-0.427	-2.649	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by USP10 expression — UCEC

Explore this box plot interactively →