USP10

Across TCGA cell cohorts, USP10 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP10-associated genes across cancer lineages are CLPS, TBATA, and IL2. Each is linked with USP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP10-to-partner and partner-to-USP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPS grouped by USP10-low versus USP10-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP10→partner) and Y-score (partner→USP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CLPS →	+0.053	+4.169	<.001	.008	3	1
CNS	TBATA →	+0.014	+4.772	<.001	.002	3	1
SKIN	IL2 →	+0.039	+5.415	<.001	.004	3	1
SKIN	PABPC1L2A →	+0.068	+4.977	<.001	.007	3	1
SKIN	OR1P1 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SEMG2 →	+0.372	+2.878	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CLPS by USP10 expression — CNS

Explore this box plot interactively →