USP1

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, USP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,388 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP1-associated proteins across cancer lineages are POLD1, MSH2, and NASP. Each is linked with USP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both USP1-to-partner and partner-to-USP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP1 versus POLD1 in PDAC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USP1→partner) and Y-score (partner→USP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACPOLD1 →+0.326+0.466<.001<.00139
LSCCMSH2 →+0.675+0.780<.001<.00139
GBMNASP →+0.637+0.611<.001<.00139
BRCAHAT1 →+0.416+0.646<.001.00139
LUADMCM2 →+0.613+0.430<.001<.00139
LUADMCM2_S139 →+0.691+0.369<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,388 associations by consensus.

USP1 vs POLD1 — PDAC

Per-sample scatter of USP1 vs POLD1 in PDAC (Pearson r = 0.45).

Explore this scatter interactively →

Exploration