USP1

Across TCGA patient cohorts, USP1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,455 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP1-associated genes across cancer lineages are PAXIP1, TUBB, and HMGB2. Each is linked with USP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP1-to-partner and partner-to-USP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP1 versus PAXIP1 in LSCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP1→partner) and Y-score (partner→USP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PAXIP1 →	+0.592	+0.638	<.001	<.001	3	4
UCEC	TUBB →	+0.738	+0.340	<.001	<.001	3	4
UCEC	HMGB2 →	+1.209	+0.307	<.001	<.001	3	4
BRCA	SNHG1 →	+0.496	+0.392	<.001	<.001	3	4
LSCC	EMSLR →	+0.726	+0.510	<.001	.008	3	3
GBM	HMGXB4 →	+0.407	+0.523	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,455 associations by consensus.

USP1 vs PAXIP1 — LSCC

Explore this scatter interactively →