USP1

Across TCGA patient cohorts, USP1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP1-associated genes across cancer lineages are PCNA, ATM, and INPP4B. Each is linked with USP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP1-to-partner and partner-to-USP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by USP1-low versus USP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP1→partner) and Y-score (partner→USP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.177	+1.874	.022	.049	3	2
UCEC	ATM →	-0.534	-1.687	.001	.040	3	2
UCEC	INPP4B →	-0.285	-2.584	.014	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.142	-1.700	.019	.042	3	1
UCEC	Ku80 →	+0.241	+1.598	.004	.011	3	1
UCEC	MEK1 →	+0.436	+2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PCNA by USP1 expression — UCEC

Explore this box plot interactively →