USP1

Across TCGA cell cohorts, USP1 mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP1-associated genes across cancer lineages are IQCF6, SCGB1C1, and DCD. Each is linked with USP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP1-to-partner and partner-to-USP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by USP1-low versus USP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP1→partner) and Y-score (partner→USP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.130	+2.397	.002	.003	3	2
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	2
BLOOD_Lymphoma	DCD →	+0.066	+5.452	<.001	<.001	3	1
BLOOD_Lymphoma	LRRC52 →	+0.822	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	CST5 →	+0.454	+5.794	<.001	<.001	3	1
BLOOD_Lymphoma	MROH2B →	+0.087	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

IQCF6 by USP1 expression — LARGE_INTESTINE

Explore this box plot interactively →