USP1

Across TCGA cell cohorts, USP1 mutation is significantly associated with the mutation status of many other genes, with 4,311 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP1-associated genes across cancer lineages are OGDHL, TRMT6, and SIPA1L3. Each is linked with USP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP1-to-partner and partner-to-USP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OGDHL grouped by USP1-low versus USP1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP1→partner) and Y-score (partner→USP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OGDHL →	+4.807	+4.807	.008	.008	1	4
BLOOD_Lymphoma	TRMT6 →	+5.247	+4.429	.005	.005	1	4
LARGE_INTESTINE	SIPA1L3 →	+2.012	+2.371	.001	.001	1	4
LARGE_INTESTINE	CHD4 →	+1.667	+1.916	.009	.009	1	4
BLOOD_Leukemia	BRSK1 →	+5.635	+6.430	<.001	<.001	1	4
STOMACH	KAT6A →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,311 associations by consensus.

OGDHL by USP1 expression — STOMACH

Explore this box plot interactively →