USH2A

Across TCGA pan-cancer cohorts, USH2A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated USH2A data layer compared with 23 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher USH2A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated USH2A expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, UCEC, and ESCA are the cancer types where USH2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	II,III,IV	0.817	0.596	.001	39	view →
UCEC	DFS	Median	All	0.830	0.594	<.001	36	view →
ESCA	DFS	Median	II,III,IV	0.274	0.540	.010	17	view →
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
COAD	OS	Median	IV	0.056	0.659	<.001	15	view →
ACC	DFS	Median	All	0.195	0.748	.003	13	view →
READ	OS	Median	III,IV	0.555	0.902	.001	9	view →
SKCM	DFS	Median	III,IV	0.455	0.711	.008	7	view →
SCLC	DFS	Median	III,IV	0.863	0.233	.017	6	view →
PRAD	OS	Median	All	0.978	0.995	.027	4	view →
LUSC	DFS	Median	All	0.450	0.349	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

USH2A–BLCA (DFS)

Open the BLCA breakdown →