USH2A

Across TCGA cell cohorts, USH2A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,197 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible USH2A-associated GO terms across cancer lineages are Positive regulation of monoatomic ion transport, Regulation of telomere maintenance, and Amino acid activation. Each is linked with USH2A in more than 5 cancer types. Because this analysis shows association rather than direction, both USH2A-to-partner and partner-to-USH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of monoatomic ion transport grouped by USH2A-low versus USH2A-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USH2A→partner) and Y-score (partner→USH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of monoatomic ion transport →	-0.054	-0.014	.004	.001	3	6
LUNG_NSCLC_LUAD	Regulation of telomere maintenance →	+0.053	+0.016	<.001	<.001	3	5
SKIN	Amino acid activation →	+0.050	+0.087	<.001	.006	3	5
SKIN	tRNA aminoacylation →	+0.050	+0.087	<.001	.006	3	5
SKIN	Positive regulation of monoatomic ion transmembrane transport →	-0.057	-0.135	.005	.003	3	5
SKIN	Negative regulation of protein localization to mitochondrion →	-0.153	-0.133	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,197 associations by consensus.

Positive regulation of monoatomic ion transport by USH2A expression — KIDNEY

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