USH2A

Across TCGA cell cohorts, USH2A mutation is significantly associated with the RNA expression of many other genes, with 1,823 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USH2A-associated genes across cancer lineages are BCAS2, ZNF404, and DNAAF3. Each is linked with USH2A in more than 3 cancer types. Because this analysis shows association rather than direction, both USH2A-to-partner and partner-to-USH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCAS2 grouped by USH2A-low versus USH2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH2A→partner) and Y-score (partner→USH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCAS2 →	+0.514	+2.000	<.001	.004	3	4
OVARY	ZNF404 →	-0.837	-3.169	.003	.007	3	4
BLOOD_Lymphoma	DNAAF3 →	+1.192	+2.087	<.001	<.001	3	4
CNS	DPH2 →	+0.476	+1.975	.002	.003	3	4
BLOOD_Leukemia	RFC2 →	+0.385	+1.820	.003	.005	3	4
LARGE_INTESTINE	RIC8B →	+0.352	+1.265	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,823 associations by consensus.

BCAS2 by USH2A expression — LARGE_INTESTINE

Explore this box plot interactively →