USH2A-AS1

Across TCGA pan-cancer cohorts, USH2A-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated USH2A-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher USH2A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USH2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

BLCA, LUAD, and UCEC are the cancer types where USH2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.134	0.577	<.001	117	view →
LUAD	OS	Tertile	III,IV	0.111	0.664	<.001	54	view →
UCEC	DFS	Tertile	All	0.756	0.901	.004	42	view →
STAD	DFS	Tertile	All	0.468	0.669	.006	36	view →
KIRC	DFS	Tertile	IV	0.165	0.624	.004	36	view →
SKCM	OS	Tertile	II,III,IV	0.141	0.340	.003	33	view →
COAD	DFS	Tertile	IV	0.035	0.487	<.001	27	view →
OV	DFS	Tertile	IV	0.959	0.422	.028	18	view →
ACC	OS	Tertile	All	0.188	0.820	<.001	18	view →
THYM	DFS	Tertile	All	0.049	0.811	.005	18	view →
HNSC	OS	Tertile	III,IV	0.958	0.717	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

USH2A-AS1–BLCA (DFS)

Open the BLCA breakdown →