USH1G

Across TCGA patient cohorts, USH1G mutation is significantly associated with the RNA expression of many other genes, with 2,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USH1G-associated genes across cancer lineages are CCNB2, PRC1, and ZDHHC3. Each is linked with USH1G in more than 3 cancer types. Because this analysis shows association rather than direction, both USH1G-to-partner and partner-to-USH1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by USH1G-low versus USH1G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH1G→partner) and Y-score (partner→USH1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.665	+2.724	.006	.003	3	4
UCEC	PRC1 →	+0.733	+2.230	.002	.006	3	4
UCEC	ZDHHC3 →	+0.309	+3.191	.009	.009	3	3
UCEC	CHAF1A →	+0.685	+2.436	<.001	.002	3	3
UCEC	SHCBP1 →	+0.602	+3.332	.003	.005	3	3
SKCM	SLC35G1 →	+0.509	+2.251	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,234 associations by consensus.

CCNB2 by USH1G expression — UCEC

Explore this box plot interactively →