USF3

Across TCGA patient cohorts, USF3 mutation is significantly associated with the RNA expression of many other genes, with 5,876 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USF3-associated genes across cancer lineages are SKA1, MCM6, and OIP5. Each is linked with USF3 in more than 5 cancer types. Because this analysis shows association rather than direction, both USF3-to-partner and partner-to-USF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by USF3-low versus USF3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF3→partner) and Y-score (partner→USF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.706	+2.598	<.001	<.001	3	6
UCEC	MCM6 →	+0.476	+1.450	<.001	<.001	3	6
UCEC	OIP5 →	+0.723	+2.053	<.001	<.001	3	5
UCEC	RFC5 →	+0.398	+1.792	<.001	<.001	3	5
COAD	GOT1 →	+0.367	+2.611	.004	<.001	3	5
BLCA	HAUS8 →	+0.392	+2.465	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,876 associations by consensus.

SKA1 by USF3 expression — COAD

Explore this box plot interactively →