USF3

Across TCGA patient cohorts, USF3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USF3-associated genes across cancer lineages are PCNA, ASNS, and Cyclin-B1. Each is linked with USF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both USF3-to-partner and partner-to-USF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by USF3-low versus USF3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF3→partner) and Y-score (partner→USF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.225	+2.915	.017	<.001	3	5
COAD	ASNS →	+0.467	+1.708	.001	.026	3	5
STAD	Cyclin-B1 →	+0.586	+3.000	.014	.036	2	4
COAD	INPP4B →	-0.347	-3.459	.015	.004	3	3
COAD	Caspase-7-cleavedD198 →	+1.131	+3.584	<.001	.002	2	4
UCEC	Rictor_pT1135 →	-0.059	-1.289	.031	.021	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

PCNA by USF3 expression — COAD

Explore this box plot interactively →