USF3

Across TCGA cell cohorts, USF3 mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USF3-associated genes across cancer lineages are SIGLEC5, TTLL8, and PBOV1. Each is linked with USF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both USF3-to-partner and partner-to-USF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by USF3-low versus USF3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF3→partner) and Y-score (partner→USF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIGLEC5 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	TTLL8 →	+0.006	+4.906	<.001	.006	3	2
SKIN	PBOV1 →	+0.009	+3.518	.003	.001	3	2
LARGE_INTESTINE	NT5C1A →	+0.019	+2.251	.005	.003	3	2
CNS	DPRX →	+0.040	+5.321	<.001	.005	3	2
BLOOD_Lymphoma	CT45A7 →	+0.130	+4.643	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

SIGLEC5 by USF3 expression — OESOPHAGUS

Explore this box plot interactively →