USF2

Across TCGA pan-cancer cohorts, USF2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USF2 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USF2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where USF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.763	0.910	.010	22	view →
LSCC	DFS	Quartile	All	0.845	0.546	.034	4	view →
PDAC	DFS	Tertile	IV	0.741	0.205	.024	3	view →
LUAD	DFS	Quartile	II,III,IV	0.787	0.995	.021	3	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USF2–HNSC (OS)

Open the HNSC breakdown →