USF2

Across TCGA patient cohorts, USF2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USF2-associated genes across cancer lineages are Heregulin, IGFBP2, and Ku80. Each is linked with USF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both USF2-to-partner and partner-to-USF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by USF2-low versus USF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF2→partner) and Y-score (partner→USF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.116	-2.986	.027	.035	3	1
UCEC	IGFBP2 →	-0.569	-1.700	.039	.044	3	1
UCEC	Ku80 →	+0.197	+1.713	.049	.027	3	1
UCEC	MEK1 →	+0.343	+2.222	.027	.011	3	1
UCEC	p62 Lck ligand →	+0.400	+2.222	.003	.011	3	1
UCEC	PDK1_pS241 →	+0.159	+2.833	.028	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Heregulin by USF2 expression — UCEC

Explore this box plot interactively →