USF2

Across TCGA cell cohorts, USF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,965 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USF2-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of Golgi inheritance, and Regulation of protein localization to nucleus. Each is linked with USF2 in more than 15 cancer types. Because this analysis shows association rather than direction, both USF2-to-partner and partner-to-USF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by USF2-low versus USF2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USF2→partner) and Y-score (partner→USF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.097	+1.216	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of Golgi inheritance →	+0.134	+0.762	<.001	<.001	3	14
BONE	Regulation of protein localization to nucleus →	+0.077	+0.877	<.001	<.001	3	13
BONE	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.123	+0.760	.002	<.001	3	13
BREAST	Negative regulation of mRNA splicing, via spliceosome →	+0.085	+0.788	<.001	.005	3	13
STOMACH	Regulation of proteasomal protein catabolic process →	+0.086	+1.102	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,965 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by USF2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →