USF2

Across TCGA cell cohorts, USF2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USF2-associated genes across cancer lineages are GHRH, KRT37, and KCNJ5. Each is linked with USF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both USF2-to-partner and partner-to-USF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by USF2-low versus USF2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF2→partner) and Y-score (partner→USF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
BLOOD_Leukemia	KRT37 →	+0.012	+4.984	<.001	.002	3	1
LARGE_INTESTINE	KCNJ5 →	+0.632	+3.263	.001	.008	3	1
LARGE_INTESTINE	ETNPPL →	+0.210	+2.436	<.001	.008	3	1
LARGE_INTESTINE	MTNR1A →	+0.352	+3.064	.005	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GHRH by USF2 expression — OVARY

Explore this box plot interactively →