USF1

Across TCGA pan-cancer cohorts, USF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USF1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where USF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.792	0.943	.002	45	view →
CCRCC	DFS	Tertile	II,III,IV	0.858	0.446	.019	14	view →
LUAD	DFS	Tertile	All	0.722	0.465	.016	8	view →
GBM	OS	Median	All	0.463	0.299	.026	4	view →
PDAC	DFS	Tertile	IV	0.741	0.199	.024	3	view →
LSCC	DFS	Tertile	All	1.000	0.693	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USF1–HNSC (OS)

Open the HNSC breakdown →