USF1

Across TCGA patient cohorts, USF1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USF1-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and Annexin-1. Each is linked with USF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USF1-to-partner and partner-to-USF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USF1-low versus USF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USF1→partner) and Y-score (partner→USF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.713	+2.189	.021	.034	3	2
UCEC	Notch1 →	+0.252	+2.179	<.001	.034	3	1
UCEC	Annexin-1 →	+0.594	+2.827	.031	.035	3	1
UCEC	PCNA →	+0.270	+3.000	.017	.036	2	1
UCEC	p27_pT198 →	+0.141	+3.321	.012	.010	1	1
UCEC	p62 Lck ligand →	+0.520	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Caspase-7-cleavedD198 by USF1 expression — UCEC

Explore this box plot interactively →