USF1

Across TCGA cell cohorts, USF1 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,510 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USF1-associated GO terms across cancer lineages are Negative regulation of membrane protein ectodomain proteolysis, Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, and Osteoblast differentiation. Each is linked with USF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both USF1-to-partner and partner-to-USF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of membrane protein ectodomain proteolysis grouped by USF1-low versus USF1-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USF1→partner) and Y-score (partner→USF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of membrane protein ectodomain proteolysis →	+0.153	+1.446	.003	.009	3	4
LIVER	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	-0.096	-0.943	.002	.001	3	4
CNS	Osteoblast differentiation →	+0.067	+1.103	<.001	.004	3	4
SKIN	Calcium ion import →	+0.123	+2.130	<.001	.002	3	3
OESOPHAGUS	Negative regulation of gliogenesis →	-0.191	-1.849	.007	.004	3	3
OESOPHAGUS	Negative regulation of lipid metabolic process →	+0.053	+1.296	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,510 associations by consensus.

Negative regulation of membrane protein ectodomain proteolysis by USF1 expression — SKIN

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