USE1

Across TCGA pan-cancer cohorts, USE1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USE1 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher USE1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USE1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where USE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.900	.012	48	view →
HNSC	DFS	Quartile	II,III,IV	0.854	0.520	.003	47	view →
PDAC	OS	Quartile	All	0.301	0.638	.005	8	view →
LUAD	OS	Median	III,IV	0.624	0.214	.045	4	view →
LSCC	DFS	Tertile	II,III,IV	0.498	1.000	.040	1	view →
CCRCC	DFS	Tertile	II,III,IV	0.563	0.813	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USE1–COAD (DFS)

Open the COAD breakdown →