USB1

Across TCGA pan-cancer cohorts, USB1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated USB1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher USB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

GBM, HNSC, and LSCC are the cancer types where USB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.660	0.788	.012	8	view →
HNSC	DFS	Tertile	All	0.728	0.519	.027	5	view →
LSCC	DFS	Median	III,IV	0.795	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

USB1–GBM (DFS)

Open the GBM breakdown →