Across TCGA patient cohorts, UROS mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UROS-associated genes across cancer lineages are RNU7-2P, RN7SL822P, and RNA5SP413. Each is linked with UROS in more than 1 cancer types. Because this analysis shows association rather than direction, both UROS-to-partner and partner-to-UROS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROS→partner) and Y-score (partner→UROS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-2P →	+0.417	+7.954	<.001	.008	3	2
LUSC	RN7SL822P →	+0.205	+5.548	<.001	.004	3	2
LUSC	RNA5SP413 →	+0.998	+6.081	<.001	.002	3	2
SKCM	PTP4A1P3 →	+0.189	+4.513	<.001	.009	3	2
UCEC	MRPL49 →	+0.726	+3.354	.001	.005	3	1
UCEC	NCAPD3 →	+0.787	+3.332	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

Exploration

UROS survival (RNA) · tumor vs normal (RNA) · all UROS data types