Across TCGA patient cohorts, UROS mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UROS-associated genes across cancer lineages are TAZ, Tuberin, and Bcl-2. Each is linked with UROS in more than 1 cancer types. Because this analysis shows association rather than direction, both UROS-to-partner and partner-to-UROS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROS→partner) and Y-score (partner→UROS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAZ →	-0.161	-2.990	.038	.036	3	1
UCEC	Tuberin →	+0.314	+3.169	.034	.020	3	1
UCEC	Bcl-2 →	-0.465	-3.143	.014	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.663	+2.827	.041	.035	3	1
UCEC	P-Cadherin →	-0.167	-3.156	.035	.020	1	1
UCEC	c-Met_pY1235 →	+0.085	+3.169	.036	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

UROS survival (RNA) · tumor vs normal (RNA) · all UROS data types