Across TCGA cell cohorts, UROS mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UROS-associated genes across cancer lineages are PCI-34051, KRAS (G12C) Inhibitor-12, and CZC24832. Each is linked with UROS in more than 1 cancer types. Because this analysis shows association rather than direction, both UROS-to-partner and partner-to-UROS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROS→partner) and Y-score (partner→UROS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCI-34051 →	+0.410	+2.646	.033	.047	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.683	+2.646	.005	.047	3	1
LARGE_INTESTINE	CZC24832 →	+0.299	+2.646	.021	.047	1	1
LARGE_INTESTINE	GSK2110183B →	+0.640	+2.649	.035	.046	1	1
LARGE_INTESTINE	123829 →	+0.656	+2.649	.023	.046	1	1
LARGE_INTESTINE	LY2109761 →	+0.438	+2.646	.007	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

UROS survival (RNA) · tumor vs normal (RNA) · all UROS data types