UROD

Across TCGA pan-cancer cohorts, UROD mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UROD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UROD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types UROD is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where UROD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UROD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.222	<.001	10	view →
LUAD	Male	All	−0.262	<.001	8	view →
LSCC	Male	II,III,IV	−0.202	<.001	6	view →
HNSC	Male	II,III,IV	−0.125	.003	5	view →
PDAC	Male	All	+0.319	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UROD–COAD

Open the COAD breakdown →