UROC1

Across TCGA patient cohorts, UROC1 mutation is significantly associated with the RNA expression of many other genes, with 4,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UROC1-associated genes across cancer lineages are LSM11, RIOK2, and MRPL22. Each is linked with UROC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both UROC1-to-partner and partner-to-UROC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM11 grouped by UROC1-low versus UROC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROC1→partner) and Y-score (partner→UROC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSM11 →	+0.280	+2.258	.003	<.001	3	4
UCEC	RIOK2 →	+0.394	+1.794	<.001	<.001	3	4
UCEC	MRPL22 →	+0.218	+2.235	.005	.001	3	4
UCEC	WDR76 →	+0.806	+1.805	<.001	<.001	3	4
SKCM	NUP88 →	+0.405	+2.738	.005	.002	3	4
UCEC	COPS3 →	+0.575	+2.000	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,788 associations by consensus.

LSM11 by UROC1 expression — UCEC

Explore this box plot interactively →