UROC1

Across TCGA patient cohorts, UROC1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UROC1-associated genes across cancer lineages are GAPDH, S6_pS240_S244, and 4E-BP1. Each is linked with UROC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UROC1-to-partner and partner-to-UROC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UROC1-low versus UROC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROC1→partner) and Y-score (partner→UROC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.571	+2.700	.029	.006	3	3
UCEC	S6_pS240_S244 →	+0.256	+1.473	.039	.006	3	3
SKCM	4E-BP1 →	+0.274	+2.700	.044	.006	3	3
UCEC	Cyclin-B1 →	+0.627	+1.947	<.001	<.001	3	3
SKCM	p70-S6K_pT389 →	-0.147	-2.000	.045	.031	3	3
STAD	PI3K-p85 →	+0.184	+3.000	.035	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

GAPDH by UROC1 expression — SKCM

Explore this box plot interactively →