UROC1

Across TCGA cell cohorts, UROC1 mutation is significantly associated with the RNA expression of many other genes, with 741 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UROC1-associated genes across cancer lineages are CELA2B, OR2F2, and TMEM82. Each is linked with UROC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UROC1-to-partner and partner-to-UROC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2B grouped by UROC1-low versus UROC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROC1→partner) and Y-score (partner→UROC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CELA2B →	+0.030	+3.297	.002	.002	3	2
BONE	OR2F2 →	+0.023	+5.169	<.001	.004	3	1
SKIN	TMEM82 →	+0.025	+3.103	<.001	.004	3	1
SKIN	HJV →	+0.020	+3.376	.004	.002	3	1
LARGE_INTESTINE	PATZ1 →	+0.617	+3.364	.001	.002	3	1
LARGE_INTESTINE	MCAT →	+0.653	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 741 associations by consensus.

CELA2B by UROC1 expression — SKIN

Explore this box plot interactively →