UROC1

Across TCGA cell cohorts, UROC1 mutation is significantly associated with the mutation status of many other genes, with 5,191 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UROC1-associated genes across cancer lineages are CDC42BPB, VPS13B, and COL2A1. Each is linked with UROC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both UROC1-to-partner and partner-to-UROC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC42BPB grouped by UROC1-low versus UROC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROC1→partner) and Y-score (partner→UROC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CDC42BPB →	+4.146	+4.146	<.001	<.001	1	5
BLOOD_Lymphoma	VPS13B →	+2.561	+3.157	.005	.005	1	5
BLOOD_Leukemia	COL2A1 →	+2.700	+3.741	.002	.002	1	5
BLOOD_Leukemia	MDGA2 →	+2.870	+3.347	.009	.009	1	5
SKIN	WNK1 →	+3.532	+3.357	.005	.005	1	5
BLOOD_Leukemia	ERBB4 →	+3.147	+5.063	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,191 associations by consensus.

CDC42BPB by UROC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →