URM1

Across TCGA pan-cancer cohorts, URM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated URM1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher URM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated URM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where URM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.410	.002	42	view →
LUAD	DFS	Median	III,IV	0.747	0.299	.002	18	view →
PDAC	OS	Tertile	II,III,IV	0.629	0.272	.009	12	view →
HNSC	DFS	Quartile	III,IV	0.629	0.822	.033	6	view →
LSCC	DFS	Quartile	II,III,IV	0.838	1.000	.027	2	view →
GBM	DFS	Median	All	0.634	0.796	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

URM1–CCRCC (DFS)

Open the CCRCC breakdown →