URM1

Across TCGA patient cohorts, URM1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URM1-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and mTOR_pS2448. Each is linked with URM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both URM1-to-partner and partner-to-URM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by URM1-low versus URM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URM1→partner) and Y-score (partner→URM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.261	-2.446	.001	.020	3	1
UCEC	JNK2 →	+0.231	+2.817	.016	.036	3	1
UCEC	mTOR_pS2448 →	-0.193	-2.980	.007	.036	3	1
UCEC	p21 →	+0.215	+3.183	.020	.009	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.637	-3.169	.003	.019	3	1
UCEC	p62 Lck ligand →	+0.456	+3.584	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK_pT183_Y185 by URM1 expression — UCEC

Explore this box plot interactively →