URGCP

Across TCGA pan-cancer cohorts, URGCP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated URGCP data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher URGCP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated URGCP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where URGCP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.841	1.000	.041	18	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.810	.005	10	view →
PDAC	OS	Quartile	III,IV	1.000	0.298	.006	7	view →
LUAD	DFS	Median	All	0.650	0.826	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

URGCP–COAD (DFS)

Open the COAD breakdown →