URGCP

Across TCGA patient cohorts, URGCP mutation is significantly associated with the RNA expression of many other genes, with 3,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URGCP-associated genes across cancer lineages are PRIM1, C4orf46, and ATG12. Each is linked with URGCP in more than 3 cancer types. Because this analysis shows association rather than direction, both URGCP-to-partner and partner-to-URGCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRIM1 grouped by URGCP-low versus URGCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URGCP→partner) and Y-score (partner→URGCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRIM1 →	+0.517	+2.130	.001	.002	3	4
UCEC	C4orf46 →	+0.553	+3.119	<.001	<.001	3	4
UCEC	ATG12 →	+0.309	+1.617	.003	.001	3	4
UCEC	SKA1 →	+0.731	+1.818	<.001	<.001	3	4
UCEC	CCNB2 →	+0.545	+1.949	.002	.002	3	4
UCEC	SAAL1 →	+0.345	+2.186	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,004 associations by consensus.

PRIM1 by URGCP expression — UCEC

Explore this box plot interactively →