URGCP

Across TCGA patient cohorts, URGCP mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URGCP-associated genes across cancer lineages are Bap1-c-4, CD31, and eEF2. Each is linked with URGCP in more than 2 cancer types. Because this analysis shows association rather than direction, both URGCP-to-partner and partner-to-URGCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bap1-c-4 grouped by URGCP-low versus URGCP-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URGCP→partner) and Y-score (partner→URGCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Bap1-c-4 →	+0.377	+3.000	.046	.033	3	3
STAD	CD31 →	-0.215	-3.000	.007	.036	3	3
UCEC	eEF2 →	+0.281	+2.222	.015	.009	3	3
STAD	RBM15 →	+0.625	+3.000	.006	.034	3	2
STAD	Annexin_VII →	-0.172	-3.000	.042	.036	3	2
STAD	Chk2_pT68 →	-0.131	-3.000	.023	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Bap1-c-4 by URGCP expression — STAD

Explore this box plot interactively →