URGCP

Across TCGA cell cohorts, URGCP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. CNS shows the largest number of these associations.

The most reproducible URGCP-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Negative regulation of autophagy, and Endosomal transport. Each is linked with URGCP in more than 17 cancer types. Because this analysis shows association rather than direction, both URGCP-to-partner and partner-to-URGCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by URGCP-low versus URGCP-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (URGCP→partner) and Y-score (partner→URGCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.166	+0.905	<.001	.004	2	18
PANCREAS	Negative regulation of autophagy →	+0.066	+0.792	<.001	.002	3	15
KIDNEY	Endosomal transport →	+0.056	+0.847	<.001	<.001	3	15
BLOOD_Myeloma	Endocytic recycling →	+0.071	+1.172	<.001	<.001	3	14
PANCREAS	Positive regulation of isotype switching to IgG isotypes →	+0.166	+0.722	<.001	<.001	3	14
SOFT_TISSUE	Cytosolic transport →	+0.063	+0.566	.002	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by URGCP expression — BLOOD_Myeloma

Explore this box plot interactively →