URGCP

Across TCGA cell cohorts, URGCP mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible URGCP-associated genes across cancer lineages are FOXS1, OPALIN, and TSSK1B. Each is linked with URGCP in more than 1 cancer types. Because this analysis shows association rather than direction, both URGCP-to-partner and partner-to-URGCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXS1 grouped by URGCP-low versus URGCP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URGCP→partner) and Y-score (partner→URGCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FOXS1 →	+0.048	+3.551	.006	.008	3	1
BLOOD_Leukemia	OPALIN →	+0.786	+3.736	.001	.005	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.289	<.001	.009	3	1
BLOOD_Leukemia	ACSM4 →	+0.060	+3.234	<.001	.008	3	1
BLOOD_Leukemia	KCNJ18 →	+0.048	+3.339	<.001	.006	3	1
LARGE_INTESTINE	SEC14L3 →	+0.021	+2.479	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

FOXS1 by URGCP expression — BLOOD_Leukemia

Explore this box plot interactively →