URB2

Across TCGA pan-cancer cohorts, URB2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated URB2 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher URB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated URB2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where URB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.440	0.813	.001	40	view →
LSCC	OS	Tertile	II,III,IV	0.950	0.638	.005	29	view →
LUAD	DFS	Tertile	II,III,IV	0.948	0.593	.002	15	view →
PDAC	OS	Median	II,III,IV	0.263	0.507	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

URB2–CCRCC (DFS)

Open the CCRCC breakdown →