URB2

Across TCGA patient cohorts, URB2 mutation is significantly associated with the RNA expression of many other genes, with 4,927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URB2-associated genes across cancer lineages are POLE2, ACRV1, and CENPU. Each is linked with URB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both URB2-to-partner and partner-to-URB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by URB2-low versus URB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB2→partner) and Y-score (partner→URB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.566	+1.523	<.001	<.001	3	4
UCEC	ACRV1 →	+0.191	+1.224	.004	.005	3	4
UCEC	CENPU →	+0.811	+1.534	<.001	<.001	3	3
UCEC	SAR1B →	+0.417	+1.847	<.001	<.001	3	3
UCEC	CCSAP →	+0.444	+1.531	.001	.004	3	3
UCEC	BUB3 →	+0.465	+2.882	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,927 associations by consensus.

POLE2 by URB2 expression — UCEC

Explore this box plot interactively →