URB2

Across TCGA patient cohorts, URB2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URB2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and eIF4E. Each is linked with URB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both URB2-to-partner and partner-to-URB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by URB2-low versus URB2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB2→partner) and Y-score (partner→URB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caspase-7-cleavedD198 →	+0.617	+2.468	.004	.011	3	3
UCEC	PCNA →	+0.216	+1.784	<.001	<.001	3	3
UCEC	eIF4E →	+0.138	+2.169	.021	.003	3	2
UCEC	FoxM1 →	+0.151	+1.398	.040	.004	3	2
UCEC	MEK1 →	+0.402	+1.784	<.001	<.001	3	2
UCEC	MSH2 →	-0.220	-1.739	<.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by URB2 expression — LUSC

Explore this box plot interactively →