URB2

Across TCGA cell cohorts, URB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,537 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible URB2-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, DNA replication, and DNA-templated DNA replication. Each is linked with URB2 in more than 19 cancer types. Because this analysis shows association rather than direction, both URB2-to-partner and partner-to-URB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by URB2-low versus URB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (URB2→partner) and Y-score (partner→URB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation involved in DNA replication →	+0.230	+1.464	<.001	<.001	3	20
BONE	DNA replication →	+0.119	+1.160	<.001	<.001	3	19
BONE	DNA-templated DNA replication →	+0.136	+1.255	<.001	<.001	3	19
BONE	DNA replication initiation →	+0.209	+1.260	.001	<.001	3	19
BONE	Double-strand break repair →	+0.097	+1.422	.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.087	+1.110	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,537 associations by consensus.

DNA strand elongation involved in DNA replication by URB2 expression — BONE

Explore this box plot interactively →