URB2

Across TCGA cell cohorts, URB2 mutation is significantly associated with the RNA expression of many other genes, with 525 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible URB2-associated genes across cancer lineages are OPN1MW2, OR52B2, and CD300H. Each is linked with URB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both URB2-to-partner and partner-to-URB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1MW2 grouped by URB2-low versus URB2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB2→partner) and Y-score (partner→URB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPN1MW2 →	+0.015	+4.087	<.001	.009	3	2
PANCREAS	OR52B2 →	+0.021	+3.786	.008	.004	3	2
PANCREAS	CD300H →	+0.046	+3.491	.007	.008	3	2
CNS	PRSS45P →	+0.046	+3.201	.003	.008	3	2
BLOOD_Leukemia	ATP1A3 →	+2.185	+3.214	.001	.006	3	2
LUNG_NSCLC_LUAD	HES3 →	+0.111	+4.212	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 525 associations by consensus.

OPN1MW2 by URB2 expression — URINARY_TRACT

Explore this box plot interactively →